CONSIDERATIONS TO KNOW ABOUT PKRRATING

The activated enzyme then phosphorylates its important substrate, the translational initiation aspect eIF2α. The ensuing translational arrest blocks viral replication. PKR belongs to a conserved family members of four protein kinases (PKR, PERK, GCN2, HRI) that each one phosphorylate eIF2α in response to diverse stimuli12, triggering the integrat